Brandy Colwell

Google says it will delete users’ location history for abortion clinic visits

Google According to a blog posted last week, users will automatically delete location history when they visit a sensitive location, such as an abortion clinic.

In the post, the tech giant stated that the location history setting in Google Accounts is turned off by default and that users who turn it on can remove data at any time. The new protections will remove entries from locations after users visit counseling centers, domestic violence shelters, fertility centers, addiction treatment facilities, weight loss clinics and cosmetic surgery clinics. The feature will be added next week.

Google also said it plans to roll out updates to Fitbit that allow users to delete multiple monthly logs at once by tracking their periods. Users can now delete one log at a time.

“We are committed to providing strong privacy protections for those who use our products, and we will continue to look for new ways to strengthen and enhance these protections,” wrote Jane Fitzpatrick, Senior Vice President of Core Systems and Google Experience, in a blog post.

“We support congressional efforts to reach a bipartisan agreement on privacy protection across the country that removes the burden of privacy on individuals and establishes good data practices across the board.”

Greater trend

Later Rowe v. Wade was overturned by the Supreme Court last month, with privacy experts expressing concern that personal data could be used as evidence that a user wanted an abortion.

Period-tracking app flow Announced last week that it would soon launch an “anonymous mode” so people could use the app without personal email, name and technical identifier. Other apps Released the statement Discuss their privacy and data sharing policies.

Meanwhile, the U.S. Department of Health and Human Services Civil Rights Office Last week the guidelines revealed how federal laws and regulations protect the protected health information of individuals related to abortion and other reproductive health care. It also clarifies what medical information is protected on personal devices such as smartphones, and advises on protecting privacy when using the health app.

There are a few senators HHS is being called upon to update the HIPAA so that patient health information cannot be shared with law enforcement agencies targeting people who have had abortions.

“When the HIPAA Act was signed in 1996, Rowe v. Wade supported the right to abortion for more than two decades,” said Senator Michael Bennett, D.C. And Catherine Cortez Masto, D-Nev., Wrote to the HHS Secretary, Xavier Bessara. “When the HIPAA Privacy Rules were enacted in 2000, it was unthinkable that the Supreme Court would take away this fundamental right after more than 20 years.”

Boron Health Benefits | Marcus Daily Apple

Everyone knows about “big minerals”. These are minerals that appear on nutrient labels or are added to fine grains and sweet cereals. You can buy these as supplements in drug stores and drug stores But while magnesium, potassium, calcium, selenium, zinc and iron are all very important for your health, they are not the only minerals you can get. There are many more minerals that are arguably important for health, although we only need them in trace amounts.

The woman pours the supplement in her hand

One of the most important trace minerals that you need to take is boron.

What is boron used for?

Boron for arthritis

Although boron will not be listed in any government recommendation or added to breakfast cereals, it is beneficial for the joints. Honestly, it’s probably essential for joints. It is not “necessary” that your average doctor or health officer know about it but it is essential for proper joint health and functioning. If you have any type of rheumatic disorder then there is a supplement to take boron. Boron accumulates in cartilage, bones, joints, and synovial fluid (the “oily fluid” that sits in the joints); People with arthritis have lower levels of boron in the joints.

A 1994 study found that boron intake of less than 1 mg / day increased between 20-70% in countries where the rate of arthritis was 0-10% in countries receiving boron between 3 and 10 mg / day.

And in one human test, 50% of osteoarthritis patients who received 6 mg / day had improved symptoms, compared to only 10% of patients in the placebo group.

Boron for bone health

Boron is also good for bones. It accumulates in the bones, determines how we metabolize and incorporate calcium, and helps control bone metabolism. The case report found that the bones of patients taking boron were harder and harder to cut than those of people who did not take boron supplements.

Animal studies show that boron supplementation can alleviate some of the skeletal deformities caused by vitamin D deficiency. If this is true in humans, having enough boron means you need less vitamin D for bone health.

Additional health benefits of boron

Although most people take boron for bone, joint and male hormone health, there are a number of broad benefits associated with supplements:

  • Improved wound healing.
  • Increasing magnesium absorption.
  • Increased levels of glutathione and superoxide dismutase.
  • Protects against pesticide exposure and damage to heavy metal deposits.
  • Improves cognitive function in adults.
  • Chemo preventative drugs reduce the negative effects as well as improve outcomes in various cancer animal models.

In other words, boron seems to help us deal with many of the problems we face in the modern inflammatory environment.

Taking boron supplements

Should men take boron?

Boron is one of the most reliable ways to increase free testosterone levels in men. Taking 10 mg of boron in the morning for 7 days increases free testosterone and decreases estrogen and sex hormone binding globulin – which binds to hormones like testosterone and makes them unavailable for use. It has reduced inflammatory markers HS-CRP and TNFO. Overall, daily boron intake improves hormone profiles and reduces oxidative stress and inflammation in men.

Boron seems to increase overall male vitality. In the case of male goats, boron intake increases sperm production, motility and quality. Boron goats produced more sperm and the sperm they produced was stronger and simply better. They were overall healthy, with strong immune systems and improved antioxidant capacity.

Should women take boron?

Women should also consider boron. Although an increase in free testosterone may not seem as relevant to women (although testosterone is also important for women), studies show that boron supplementation can help increase their bone mineral density and reduce menstrual pain.

How much boron do you need?

In most studies the dose is used between 3-10mg per day. It seems safe, well-tolerated and physically normal.

What is a good boron supplement?

I have used trace mineral boron drops — they are easily and seamlessly mixed in coffee or water that have no taste. These boron capsules are also good to look at.

Some people even create their own boron concentration using borax or sodium borate. This is something you use in your kitchen to kill invading ants, use as a cleaning agent or add to washing machines. It turns out that sodium borate is only toxic to humans in high doses. If you dose it correctly, you can use borax as a dietary supplement. But you have to be careful. Borax is roughly 11.3% boron, so one gram of borax প্রায় about a quarter teaspoon মূল্য would contain 113 milligrams of boron. Add it to a measured amount of water and take a small amount daily to get the desired dose of 3-10 mg.

Why should we supplement boron? Is food not enough?

In most places food is not enough. Pruning, raisins and other dried fruits are probably the best sources, followed by legumes, avocados, wine and grains. Boron soil levels (and thus food levels) vary widely and are usually supplemented to achieve physiological benefits and needs.

If you are interested, you can always Google “[your location] Soil boron levels to get an idea of ​​your locally grown food and how much boron is entering groundwater. However, since many of us eat foods grown in other regions, and the amount of boron in the diet is not really tracked, it can be difficult or impossible to determine how much boron you are getting in your diet. That’s where a supplement can really help.

Low dose boron supplementation in the range of 3-10 mg / day is physiologically normal, safe and effective. It accumulates in bones and joints when found in food and when taken in small amounts it improves hormone status, inflammatory markers and bone metabolism (among other effects). All signs indicate that boron is an important, beneficial trace mineral. I see no reason not to take boron.

Do you ever take boron? Did you notice?

Primary Kitchen Disney Mustard

About the author

Mark Season is the founder of Mark’s Daily Apple, the godfather of the early food and lifestyle movement New York Times Its bestselling author Keto Reset Diet. His latest book Cato for life, Where he discusses how to combine the keto diet with early lifestyle for optimal health and longevity. Author of many more books, including Mark Early blueprintWho was credited with turbocharging in 2009 for the growth of the early / Paleo movement. After three decades of research and education on why food is a key ingredient for achieving and maintaining optimal well-being, Mark started Primal Kitchen, a real-food company. Which forms the main component of Primal / Paleo, Keto and Hole30-friendly kitchens.

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Teletherapy startup Sensible Care raised 13M

Sensible Care Skyline, a provider of teletherapy, has scored $ 13 million in a series of funding rounds led by Volition Capital with the participation of investors.

What does this mean?

Founded in 2017, the startup provides virtual therapy and psychiatry services For patients, Including children and couples. Provides sensitive care personally Transcranial magnetic stimulation, a therapy used for patients with depression who do not respond to or cannot use medication.

The company currently operates in California, but plans to use the investment to expand and further develop its platform. Sensible Care says it will focus on states with large populations of patients covered by Tricare, health plans for military service members and their families, such as Texas, Florida and Virginia.

“Our goal is not only to provide patients with on-demand access to mental health care services but also to do so with a level of quality in the long-term patient-provider relationship, which is the foundation of any traditional practice,” CEO Paul Kim said in a statement.

“After experiencing the frustrating barriers to accessing quality mental health care personally, especially for military veterans, my co-founders and I are ready to create a solution that allows patients to access their insurance benefits while paying for providers through technology-enabled employment. Makes the most of it. “

Snapshots of the market

Mental healthcare continues to make up a large portion of telehealth use. According to FAIR Health’s monthly telehealth regional tracker, Mental Health Diagnosis was 64% of the telehealth claim line in April.

Although digital health funding has slowed overall in the first quarter of this year, Rock Health has discovered that mental health is still the top-funded clinical field, bringing in $ 1 billion.

Another company providing virtual psychiatry services is Iris Telehealth, which offers its services along with healthcare, hospitals and community health centers. It has recently announced to raise it বি 40 million in Series B funding.

In December, Hybrid Mental Health Startup Uplift Has scored $ 8 million to add psychiatric medical services and expand geographically. Another psychiatric care startup, TalkieTree, added rounds to the $ 37 million series in early 2022.

The FDA banned Jules during a review and allowed her to stay in the market

The Food and Drug Administration has decided to temporarily allow Jules Labs’ vaping products to remain on the market, citing “scientific issues” that could lead to a review of the agency’s ruling last month to ban the company’s e-cigarettes.

The agency’s decision to conduct an internal review effectively took the dispute out of public view in the Court of Appeal, where Jules was initially granted a temporary release and returned it to the agency’s personal administrative process. But the FDA has warned that its latest move, first Announced in a tweet On Tuesday night, the decision to withdraw the original order should not be misunderstood.

The FDA’s decision is a turning point in Jul’s journey to seek government approval under the rules, which must prove that it and other companies do more good for public health than harm their products. It was blamed for the juvenile steam crisis more than four years ago, sparking widespread outrage from parents, schools and local policymakers, as well as Congress.

On June 23, the FDA surprised many when it issued an order to Jules to stop selling its e-cigarette products in the United States. In a statement, the company said Jul’s applications were “lacking evidence” to stay on the market to prove that they would benefit public health and included “insufficient and conflicting data” about “potentially harmful chemical leaks” from its e-liquid pods.

The ban was celebrated by those who said the company should be held responsible for tempting teenagers to use the product with its attractive mango and cream brulei flavors and youth-advertised ads. They panned on the FDA’s decision to point to e-cigarettes that switched to devices as a stop option for millions of adult smokers, which is widely credited with being less toxic than conventional cigarettes.

Vaping companies have had to seek FDA approval to sell their products, and many are now going through that process. The FDA says it has approved several vaping devices and denied more than a million applications.

For its part, Jules has already made a brief appeal in support of a long-term appeal to the U.S. Court of Appeals in Washington, D.C., calling the agency’s ban “discriminatory” and accusing it of “threatening” behavior.

In a briefing filed last week, Jules argued that it has helped two million adult smokers quit traditional cigarettes. Jules added that it was treated unfairly, noting that it was isolated by members of Congress who pushed the agency to boycott the agency.

Jules added that it had only one chance to address the FDA’s concerns before issuing the denial. In contrast, other agencies were allowed to submit 14 amendments to their applications, Jules said in his court filing.

The FDA has not released documents outlining the reasons for rejecting Jul’s marketing application. Filing in Jul’s court said the agency claimed “in more than two dozen places” that Jul had not provided adequate information on the four chemicals.

The company’s filing states that four chemicals were identified in a study that tested toxic substances in e-liquids from its plastic pods, which evaporate when heated and are inhaled by users. The agency said in its court briefing that none of these chemicals were present in the joule study listed in the makeup of the aerosol plum of its device.

Jules said it provided thousands of pages of data so that if those chemicals could be detected in aerosols, they would be released.

Dr. Laura Crotte Alexander, an e-cigarette researcher and associate professor of medicine at the University of California, San Diego, has published a critical study of the effects of the jull device on the rat brain.

But after reviewing the company’s court papers, he said his argument was understandable: it is possible that the chemicals displayed in the liquid turned into a different compound after being heated and evaporated. Dr. Croti Alexander says that happened in his own research on the chemistry of e-cigarettes.

“It is not surprising that a chemical that was originally liquid is not an aerosol,” says Dr. Crotte Alexander. The name of the chemical in question was corrected, he noted, making it difficult to further evaluate.

Joel Murillo, Jul’s chief regulator, said the chemicals in the liquid “cannot be transferred and detected in the aerosol due to a variety of factors, including compound instability or chemical composition.”

In his court filing, Jules insisted that the FDA had all the information needed to see if any leached chemicals could be detected in his aerosol.

Jules “provided that information – 6,000 pages of it,” the company said in its filing. “If the FDA had done a more thorough review (as it did for other applicants), it would have seen data that those chemicals are not observable in aerosols that Joule users breathe.”

Theodore Wagner, director of The Ohio State University’s Center for Tobacco Research, said the agency’s initial ban was interesting because independent research teams, including his own, have found that joule devices are much less toxic than conventional cigarettes.

“Joule aerosols definitely have significantly lower levels and less toxic substances than cigarettes,” said Dr. Wagner, adding that Joule’s devices contain lower levels of chemicals than other e-cigarettes. “That’s what surprised me.”

Pediatric neurosurgeon J. Wells discusses the reversal of ‘Row vs. Wade’:

Pediatric Surgeon.

XiXinXing / Getty Images / Xixinxing

Pediatric Surgeon.

XiXinXing / Getty Images / Xixinxing

Pediatric neurosurgeon J. Wells regularly feels the urge to save a child from certain death – and sometimes the pain of failing to prevent it. He has performed operations on various parts of the pediatric central nervous system, including surgery on the spine of an in-ero fetus to correct spina bifida.

“Depending on the size of the fetus, [the spine] Can be really small, [like] Three grains of rice, “Wellness says.” We use our magnifying loops, these surgical loops, the magnifying glass that we wear, and then we turn on a headlight so we can see what we’re doing. “

Wellness, who hails from southern Mississippi, said he did not want to be a pediatric surgeon. When he first went to medical school, he imagined himself as a small-town family medicine doctor who could “occasionally pay for tomatoes and chickens.” But a gross anatomy lab where he learned about the spinal cord and nerves of the brachial plexus changed his path.

“I remember spending hours and hours dissecting it and absolutely getting through it. It was like McCormick,” Velons said. “It started when I realized that I could start with a great career in family medicine, which would be very fruitful, in a completely different career.”

Wellness’s memoirs reflect his experience as a pediatric surgeon, All that moves you. He says he has a large book of pictures and memorabilia of his patients that he pulls out whenever he needs to be lifted up or thrown to the ground.

“I would always pull out that file and just flip through it and just think, ‘That’s why we do what we do,'” he said. “Because it’s a deep night. It’s a lot of hours for the residents and for us on the field. But that amount of gratitude – I mean, I felt it as a patient. I felt it as a parent, and I experienced it as a surgeon.”

Interview highlight

All that moves youBy J. Wells

Penguin Random House

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Penguin Random House

All that moves youBy J. Wells

Penguin Random House

How Invert Rowe vs. Wade Will affect patients who have fetal neurological defects

I will tell you a story about my niece and my niece allowed me to talk about it. My niece … calls me one day after being a few weeks pregnant and says, ‘I’m with OB, we did our 13-week ultrasound and they say I have a brain problem and they say I want to come see you, Uncle J. ‘ And we take her to the fetal clinic, we do the ultrasound. I stay with them all the time – my niece, whom I have known since childhood, my kids walked to her wedding – and have this encephalosel. It’s a monster. And the whole brain is outside the skull and it’s kind of inverted. So now it’s also at the mercy of amniotic fluid, the caustic fluid that becomes more caustic over time, which is why fetal surgery makes a difference for spina bifida.

Dr. J. Wells is a professor of neurological surgery at Monroe Carell Junior Children’s Hospital in Vanderbilt and Vanderbilt University Medical Center.

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Dr. J. Wells is a professor of neurological surgery at Monroe Carell Junior Children’s Hospital in Vanderbilt and Vanderbilt University Medical Center.

Susan Urmi / Penguin Random House

So in that scene, the choice is a child who is finally born, who is in constant pain, who does not have the ability to communicate or see or communicate with the world around them. They are in a wheelchair, the type of wheelchair that holds your neck. They are fed G-tubes and over time they do not grow from baby. They become adults who have the level of care they need. Earlier in such situations, with other patients, we talked about termination and with my niece we talked about this. …

We are now going to see many more of these and we as a society need to understand that we need to take care of these children. That is our job.

When performing in-vitro surgery to correct spina bifida on a fetus

Mom came into the operating room, she went to sleep, lines were laid, her stomach was prepared. And then there’s a whole team called MFM, the team for maternal fetal medicine. … So the abdomen is prepared, an incision is made, the uterus is exposed. It’s like an orange-pink football ball. And the team will do an ultrasound of the uterine dome, find a good place to open it, make an incision, reveal the inside of the uterus, where the fetus is. And so, all of a sudden, like 20 to 22 weeks, we’re looking down there at what has been rotated in place. And that’s the moment when we repair the back to stop it to reduce some long-term sequels that could happen from Spina Bifida.

Being a guardian and dealing with the deaths of his patients

I think you need to actively double when you’re in the middle of it, especially if you have children and you’re a pediatric neurosurgeon. It’s almost like I imagine myself pressing a clutch to turn that gear off. It’s not that easy. …

[I] There are places like this where I go that is out of my sight, and it’s a beautiful green field that I think of. I can take such memories and experiences [patients] And I can imagine putting them in a box. I don’t like to forget these kids. It’s just that it’s a place where we keep them. And I think it’s a common feeling among surgeons to deal with things like life and death.

On the importance of explicit communication with the families of his patients

As much as you want to punch, or as much as you don’t want to say it, or as much as you don’t think you can take it if you are told it, it’s still your job to make sure they know and they understand. That doesn’t mean you can’t deliver without sympathy: “I’m sorry to have this conversation with you, but your daughter is really sick and we need to take her to the operating room right now.” So to some extent, it’s important to make sure they understand the situation, to make sure they understand what the plan is … to make sure they understand what’s happening, to make sure [they know] Tell them what the risk is and then what we’re going to do. And then staying with them, not moving away later, going after the surgery and talking to them and then, [making rounds] As much as you need in the ICU, and I think it’s critically important as well.

Assault weapons as a public health problem

I’ve seen some really horrible injuries from gunshot wounds, and it’s not specific to a weapon attack, but I’ve seen some injuries to the brain and spine that left a girl paralyzed, in a quadruped position on a ventilator. And it has been part and parcel of a society where there are guns in them. … What we see today with these assault weapons is a lot of damage. I have a friend, John Martin, who is the head of pediatric neurosurgery at Connecticut Children’s Hospital. And after Newtown [Sandy Hook] Shots, he describes, are all dressed and waiting for the kids to get to the hospital until they realize that so many people have died because no one is really coming. And I’m having a hard time understanding why we need this weapon in society.

Sam Brigger and Seth Kelly created and edited this interview for the broadcast. Bridget Bentz, Molly CV-Nesper and Laurel Dalrymple have adapted it for the web.

Study: Decentralized and remote technology increases interest in clinical trials

Remote technology and decentralized clinical trials may increase patient participation, according to Published in the study Clothing network open.

Researchers surveyed 1,183 cancer patients and survivors about their interest in clinical trials and willingness to use remote interventions. Only 18% of cancers participated in clinical trials. Meanwhile, 77% said they would join a trial if the distance and frequency of visits were as easy to access as their regular care, and 47% said they would participate even if additional travel time or visits were needed.

Patients older than 55 years were significantly more likely to say that they would not participate in trials requiring travel longer than their usual place of care, while respondents from higher-income families were more likely to participate in the study that required additional effort.

More than 80% were willing to use remote interventions, such as delivering and receiving oral medications at home, providing electronically informed consent, and using apps or wearables. The study found that the use of remote options was associated with an increased desire to participate in clinical trials in all groups, especially those who showed the highest interest in trials, but also with respondents who initially said they did not want to be admitted to one. Judgment in any situation.

However, 86% of respondents said that it is important to have the option of personal inspection during a completely remote clinical trial.

“In this cross-sectional study of patients with cancer and survivors, most respondents have expressed a strong desire to participate in clinical trials of cancer. Changed, ”the researchers wrote.

“The use of remote technology and other decentralization tools that could reduce the need to travel to a trial site was associated with an increase in the chances of a self-reported patient participating in cancer trials.”

Why it matters

The authors of the study focused their survey on hypothetical clinical trials and did not measure whether interest matched actual trial participation. Meanwhile, clinical trials of cancer may vary in the intensity of the intervention, which may influence the decision to enroll patients. Respondents to a survey may also be more likely to show interest in a clinical trial than the general population.

However, the researchers said their survey shows that patients receive decentralized testing, which may help lower-income and older patients participate.

“Our data show that cancer patients and cancer survivors are more receptive to these technologies and tools, and that the use of the test context is associated with increased self-reporting possibilities if the technology or equipment reduces travel requirements. A trial site ৷ The degree to which you are more likely to participate in a trial varies by method, and the ability to have the option of a personal visit to a trial site whenever you wish was important, “they wrote.

Greater trend

Like other remote healthcare equipment, decentralized clinical trials COVID-19 gained traction during the epidemic. Diversity among clinical trial participants is also an ongoing concern, which according to some experts can be improved by adding virtual or remote flexibility.

In the meantime, there are several companies that offer decentralized clinical trial technology, including Curebase, Refine Health, Medable and Thread.

Cancer drugs greatly reduce the mortality of hospitalized covid patients

According to a study published on Wednesday, covid, an experimental drug initially designed to fight cancer, has halved the risk of death in hospitalized people.

The drug, sabizabulin, seems to be more effective than others approved for critically ill covid patients. Veru has applied to the Food and Drug Administration for urgent approval for the use of the drug, which the Miami company has developed. This will probably add a new weapon to the moderate arsenal available for hospitalized patients, experts say.

“It looks extremely impressive,” said Dr. Ilan Schwartz, an infectious disease specialist at the University of Alberta, who was not involved in the study. “We have a small number of treatments for patients with serious illnesses that improve mortality, but another treatment that can further reduce mortality would be very welcome.”

Dr. Schwartz warned, however, that the trial was relatively small, with only 134 patients taking the drug. “Overall, I think it’s very exciting, although I would welcome larger and independent confirmation research,” he said.

Sabizabulin prevents cells from forming microtubules, vital molecular cables that shuttle components from one part of the cell interior to another.

The drug was originally developed by researchers at the University of Tennessee to fight cancer because fast-growing tumor cells rely on microtubules for their rapid growth.

Two years ago, Veru’s researchers tried Sabizabulin on Kovid. They suspected that the drug could inhibit viral replication, relying on microtubule networks to assemble fragments of new viruses.

They further speculated that the drug would help covid patients fight potential life-threatening pneumonia. This immune response begins when cells detect that they are infected and release alarm-signaling proteins around them. The cells have to push the alarm molecules along their microtubules to get the sound out.

In early 2020, researchers at the University of Tennessee Health Science Center found that Sabizabulin reduced these alarm signals in mouse cells. A few months later, Veru began testing the drug, which was taken as a pill, in humans. In May 2021, it proceeded to a late-stage trial.

The agency wanted volunteers already in the hospital for Kovid. To qualify for the test, patients had to take oxygen or rely on a ventilator. With risk factors such as high blood pressure, advanced age or obesity, they had to be at high risk of covid death.

Patients were simultaneously allowed to receive other treatments that have been shown to be effective in saving the lives of hospitalized covid patients. For example, a steroid called dexamethasone reduces the risk of death by one-third.

In the latest test, 134 volunteers received Sabizabulin and 70 received a placebo. Within 60 days, the mortality rates between the two groups were significantly different: 45.1 percent of the placebo group died compared to only 20.2 percent of those who took the new drug. This difference translated into a 55.2 percent reduction in mortality risk.

Dr. David Boulevard, an infectious disease specialist at the University of Minnesota, warned that the large number of deaths in the placebo group could be a sign that the study was too short to reach a firm conclusion.

“The 45 percent mortality rate in the control group seems to be higher than mine,” he said.

In contrast, in an arthritis drug trial called baricitinib, the researchers gave the drug to 515 covid patients and received 518 placebo. Only 7.8 percent of the placebo group died.

Many antiviral drugs have been shown to be effective in keeping covid patients out of the hospital, but only if they are given early in the course of the disease. Paxlovid, for example, can reduce the risk of hospitalization in immunized individuals with covid risk factors by about 90 percent.

These drugs do not work well, however, on hospitalized patients with moderate to severe covidosis. This is because they only block the virus without controlling the immune system’s response to the escape.

For hospitalized patients, doctors have fewer medications to choose from. In addition to dexamethasone and baricitinib, another anti-inflammatory drug called tocilizumab has been found to help.

When Veru announced its results early in April, the company said it had initially closed the trial because an independent advisory committee had found that Sabizabulin’s benefits were already clear from the data; It would be unethical, they decided, to continue giving some patients placebo.

Although Dr. Boulevard acknowledged the ethical claims of the situation, he also predicted that if the trials were prolonged, the benefits of the drug could emerge as more modest.

“Trials that are closed early routinely over-evaluate the impact,” he said.

Dr. Boulevard noted that the Covid drug Malnupiravi initially reduced the risk of hospitalization from Covid by 50 percent. But in the final analysis that number dropped to 30 percent.

He predicted a similar fate for Sabizabulin. “I would be skeptical that the effect is 55 percent,” Dr. Boulevard said.

The quest of circadian medicine to make the most of our body clock

His observations have resonated with circadian scientists who are struggling to move forward in their own institutions. “John has been able to raise awareness about discussion,” said Elizabeth Clarman, a professor of neurology at Harvard Medical School, who works in the sleep division at Massachusetts General Hospital. Frank Shearer, director of the medical chronobiology program at Brigham and Women’s Hospital, was also impressed. “We are trying to improve the health of the most at-risk, we have a responsibility to take care of them, and yet, they are in an environment that is not conducive to sleep,” he told hospital patients. “I think his work is beautiful. He is making great progress in this area. ”

Although PNAS data revealed that when hospitals dispense drugs are probably more effective than medical money, it has not been able to show whether it harms patients at that time. If it is not, why change it? Hogenesch’s team and colleagues at other hospitals are now analyzing electronic medical records to see how well they affect certain generic drugs. This is harder to hear, because the data that hospitals collect is primarily for billing, not for research, and does not always specify when patients receive services and medications. If patients’ electronic medical records – blood drawings, vaccines, urine and other sampling procedures – are timed, it can greatly improve our understanding, G notes. “Your vaccination record does not say when you received it.” But it should be “so easy,” he added. “It’s all electronic.”

Any data collected from medical records will still be observational, but the more information you have from different sources, the more persuasive it can be. In the meantime, researchers can look at multiple small studies collectively called metanalysis to create larger and more representative samples. Last year, to help with the case that medications can have a big impact over time, Hogenesh and colleagues published as a preprint, before peer review, a metanalysis of previous clinical trials that included daytime topics that included 48 pharmacological or surgical treatments. Unexpectedly, low-dose aspirin, which millions of people take every day to prevent cardiovascular disease and does not come with guidelines on when to take it, proved to be the most time-sensitive: in eight out of 10 studies it was given in the evening as opposed to in the morning. If effective.

Personalized circadian medicine The future may be. The time of our clock varies individually, set by the sun, the light of the house, the genetic predisposition, our behavior, our age, by each other. Scientists are still scrambling to come up with a quick and easy way to tell where your organs are. But for now, you don’t need perfect precision to improve the coordination and strength of your biological rhythm. Circadian researchers generally recommend getting as much sunlight as possible during your day, especially when you wake up, dimming the light before bed and darkening your bedroom. (Parking in America at standard time, not in broad daylight, will help you get it done.) Front-load your calories at the beginning of the day. Above all, try to keep your schedule comparable throughout the week, including weekends. “There’s room to think about overall health optimization – improving mood, improving overall health,” Helen Burgess, a professor of psychiatry and co-director of the Slip and Circadian Research Laboratory at the University of Michigan, told me. “We are all getting old. Many of us feel like we are fading, ”he added. “Can I do small things to feel good?”

Circadian drugs can increase our well-being in other words, but most of us should not expect that it will change our lives anytime soon. Although there are exceptions to that rule whose abnormal situation may later point to a larger application. As Hoganesh told me, “You will learn from the case of the edge.”

Shortly after he arrived in Cincinnati, a Boston colleague forwarded him an email from the parents of teenage Jack Grosseclos with Smith-Kingsmore Syndrome, a very rare condition caused by mutations in a single gene that causes pain and convulsions, developmental delays, and autism. The nature of harm. In their letter, Mike and Kristen Grosseclos explain that Jack is taking a drug to stop the gene. It improved many of her symptoms, but her sleep took on a bizarre pattern. For more than a week, he slept no more than an hour or two and instead moved at a constant pace. (His parents congratulated him on a Fitbit he bought to track his activity.) Then, seven to 10 days, he slept 14 hours. “After 10 days of little sleep, his body began to break down,” they wrote. “He became limp and restless, breaking into eczema.” Jack’s doctors were shocked. In hopes of creating an explanation, Grosecloses included a bar graph of Jack’s sleep cycle and a picture of him in their email. “He was looking bad,” Mike told me. Kristen added, “We thought a visual aid could help.”

Most Americans say that life has begun to return to pre-Covid normalcy, a poll shows

Most Americans say their lives are at least getting pre-epidemic back to normal, according to a recent study.

According to a survey published Tuesday by the Associated Press-NORC Center for Public Affairs Research and The Scan Foundation, 12 percent of adults think their lives are somewhat similar to what they were before the epidemic, 54 percent. .

A small proportion, 34 percent, think their lives are not the same.

The survey was conducted in mid-May, when, as of now, the number of hospital admissions is rising nationally.

According to the survey, a slim majority of 51 percent of Americans think that a Covid-19 vaccine is essential for them, while 39 percent think that almost all people need to be vaccinated before the situation returns to normal.

Fifty percent of Americans believe that the availability of effective treatment for Covid-19 is essential for participation in public life.

Only 22 percent think wearing a mask in a public indoor place is essential to getting back to pre-epidemic life, while 20 percent think regular testing is essential.

The study also found that black and Hispanic adults are more likely to emphasize indoor masking and regular testing than white adults.

While 78 percent of black respondents said most people would return to normal life wearing masks in public indoors, 62 percent of Hispanic and 44 percent of white respondents agreed.

When asked if most people should be tested regularly, 71 percent of black people said yes, compared to 58 percent Hispanic and 42 percent white people.

In the survey, 87 percent of respondents said they would hang out with friends and family; 79 percent planned to visit a bar or restaurant, visit elderly relatives, travel, and attend private religious services; 65 percent said they are ready to exercise in a gym or studio; And 50 percent will use public transportation.

South African teenagers remember suffocating gas, a stampede and an exit

EAST LONDON, South Africa – Simbangail Emtsweni was laughing for a gas-like air that felt like fire in his nose and lungs before he stepped out into the fray. “When I got there,” he said, “I was on the second floor and started vomiting when I realized I was lying next to a dead man.”

Hundreds of young people, drawn by a notice on Facebook promising a party at the end of the school term with free alcohol and Wi-Fi, crowded a small, packed inn in East London, a town on the south coast of South Africa.

Twenty-one of them, all teenagers, will not live at night. A mass funeral will be held with President Cyril Ramaphosa on Wednesday.

Eyewitnesses, investigators – the entire nation – are struggling to understand how a happy night turned into a fatal stampede, leaving broken and bloodied young men on the floor of the Enobeni Tavern in East London’s Scenery Park Township.

“We’re here for fun, not for corpses,” said Lubabalo Dongeni, an 18-year-old high school student.

Authorities have not given an account of why the man died or published the results of the autopsy, but the public and authorities have found plenty of targets for blame and anger. The hastily licensed inn, with two floors and just one entrance, is being scrutinized, the couple running it are under criminal investigation, and a DJ performing there says the community is “beying” for his blood. There has been widespread speculation about the toxic gas that filled the air, who released it, and whether it contributed to death, panic, or both.

The six people who were inside the inn, as well as others outside, said in an interview that a combination of mysterious gas, a human crash and an airless room could be the cause of the tragedy.

City residents are furious with the local police for taking hours to respond to emergency calls. Outside of East London, the episode has sparked a national debate about juvenile alcoholism and the place of alcohol in South Africa. Some point to other systemic failures, ranging from the location and construction of the inn to the lax enforcement of the liquor license law in the township.

The dead were under 13 years of age and mostly under 18 years of age. The legal age for entering a bar and drinking in South Africa is 18 years.

The teenagers who were there that night apparently suffered trauma.

Members of a high school boys’ soccer team were in the inn, but a midfielder and goalkeeper never found out. The team striker says he is now struggling with the guilt of surviving.

A 19-year-old blames himself for helping his 17-year-old friend go to a party where he died. Recently, when a group of teenagers entered the inn to spread white plastic roses, they were overwhelmed with emotion.

The entrance, a single metal door painted brown, was the epicenter of chaos that night. The party was supposed to end at midnight on Saturday, June 25, but outside, according to video taken with cellphones, dozens of people were still trying to get inside. After 12:30 pm, the inn went dark, but no one jumped – a blackout of electricity is a common occurrence in South Africa.

But as soon as the flashing disco lights returned a few minutes later, a gas leaked through the ground floor, survivors said. Some say it smells like pepper spray, while others compare it to tear gas.

People rush to get out, when outsiders try to get in on a cold winter night. That’s when the bouncers closed the door, eyewitnesses said, keeping everyone inside.

When dance music, a popular local style called amapiano, hit the second floor, people on the ground floor climbed on top of each other to get out, breaking two windows in a room larger than 350 square feet.

Brian Mapisa, a rapper who had just finished his set on the second floor, said he could hear panting around him. He was making his way down to the exit when the door closed and the crash started. The trapped people pressed so hard against him, his legs numb.

Two men bit him when they tried to climb on him, he recalled, even six days later the semicircle of the knife in his arm was red. Mr Mapisa said the gas was shaking as soon as it touched his wound. He felt desperate, drowning on his knees.

The song only ceases when the sound of screams spreads, the survivors remember. Neon lights, brown murals jumping from rolling yellow walls, illuminated bodies scattering on the dance floor and friends unable to revive them.

Some people jumped from the second floor. Only then did the bouncers open the door alone to take some of the bodies out, several survivors said.

The window of Nalitha Khekazar’s bedroom is a few feet away from the entrance of the inn. When people jumped from the porch, they landed on his roof. The dead and injured teenagers were lying on the lawn in front of him, he said. A girl with a broken leg was lying on the floor of her dining room until 8 am

Early that Sunday morning, Mrs. Khekaja, a 55-year-old grandmother, called the police 10 times between 2:25 and 3:35, showing her call logs.

Police and ambulances finally began arriving around 4 a.m., neighbors said. As officers cordoned off the area, guardians tried to pass the tape. Some unconscious victims were still inside the inn, lying on the plaid couch or just on the dance floor – dead and injured as well.

Pictures of the scene spread on social media. This is how some parents found out that their children went out that night, but they died.

“My son was showing a tendency,” said Sidwell Rangil, the father of football goalkeeper Embulelo Rangil.

Unable to find his son at the local hospital, Mr Rangil rushed to the morgue. At first, she could not recognize her son’s body in the rows of corpses because the boy’s skin had become so black. Another victim, a 17-year-old, was similarly unidentified hours after his death, according to his friend, Shenzhen Jungo Futumni, who was in the inn.

Even grieving parents like Mr. Rangil have faced criticism for the heavy news coverage of the disaster.

“If the finger is to point, it must point to all of us,” he said. “But it’s wrong to blame us.”

The owners of the inn, Siakhangela and Vuyokaji Ndevu, have shouldered a lot of public condemnation.

The inn, which shares a wall with several private homes, has long divided the community, where residents gradually used their savings to build their homes. Neighbors complained of urine stains on their walls and empty bottles scattered outside, partying until 8am and children vomiting in their garden.

Ndevus declined to comment.

Several neighbors said they met with police and an inspector from the Eastern Cape Liquor Board just three weeks before the disaster. But both the liquor board spokesman and police say they have no record of any complaints about the inn.

The inn’s license was granted in 2012, but the Wine Board was unaware that the owner had added a second floor in recent years.

Last week, the Wine Board filed a criminal lawsuit against Vuokazi Endeavor, in whose name the license was issued, for selling alcohol to minors. Police did not say whether they would file charges against him.

Nationally, the conversation has turned into South Africa’s alcohol abuse and uncontrolled taverns, especially in the poorer, mostly black towns. According to the World Health Organization, more than half of people in South Africa do not drink alcohol, except those who complain of heavy drinking.

In Scenery Park, where drug use is on the rise, going to pubs for drinking is popular among teenagers, and is seen as less bad, says soccer coach Ludumo Salman, who started a soccer club for high school students.

“I hope this is going to be a wake-up call, because it’s a reality across South Africa,” said Esteth Sotheny, who runs a nonprofit for young people in East London townships.